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Table 2 Selected gene homologies relevant to this work

From: The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1

Halobacterium

Bacteria

S. cerevisiae

S. pombe

human

Function

rad2 1

 

RAD27 1

rad2 1

FEN-11

structure-specific endunuclease makes 3' incision in base excision repair

rad3a, rad3b

 

RAD3

rad15

XPD

5' to 3' helicase

rad25a, rad25b

 

RAD25

 

XPB

3' to 5' helicase

  

RAD2

rad13

XPG

makes 3' incision in eukaryotic NER

eif4a

 

RAD1

rad16

XPF

makes 5' incision in eukaryotic NER (with RAD10/ERCC1)

uvrA, uvrB, uvrC, uvrD

uvrA, uvrB, uvrC, uvrD

   

recognition, incision and removal of damaged DNA in bacterial NER

  1. Notes
  2. 1 S. cerevisiae RAD2/human XPG belongs to the same multigene family as S. cerevisiae RAD27/FEN-1 but the Halobacterium sp. NRC-1homolog, rad2, is more closely related to RAD27/FEN-1. There is no other homolog in Halobacterium sp. NRC-1.